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Es ist jedoch wenig zur genauen Pharmakologie und Toxikologie der synthetischen Cannabinoide bekannt, und es wurden nur wenige offizielle Humanstudien veröffentlicht. Möglicherweise haben manche Cannabinoide neben ihrer hohen Wirksamkeit besonders lange Halbwertszeiten und fileühren wohl zu einer verlängerten psychoaktiven Wirkung.
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